Alternate Solutions to Consider
Hooking up DotNetNuke or other Web/Desktop applications to an external source is an exciting and "sexy" thing. That is why I love Web development. Static Web pages are boring, and so is pure database development. Below are most of the possible connection strings for DotNetNuke and other applications. If I'm missing one, please let me know. I'll add it to the list. This is a very popular page.
Before you can install and run DotNetNuke, you need to create/configure a Database or datasource. Then you need to point your connection string to your data source.
About DotNetNuke (DNN) Connection Strings
DotNetNuke (DNN) Connection Strings for Microsoft Products
including all SQL Server versions, Excel, Access, Text, FoxPro and Paradox
DotNetNuke (DNN) Connection Strings for Oracle
DotNetNuke (DNN) Connection Strings for MySQL
DotNetNuke (DNN) Connection Strings for Other Database Products
including Visual FoxPro, Firebird, Pervasive, IBM DB2 and others